Victoria

Peter MacCallum Cancer Centre - Melbourne Peter MacCallum Cancer Centre

Chief Investigator: Professor Wayne Phillips

Peter MacCallum Team - PROBE-NET

Using novel in vitro culture models to investigate the role of bone morphogenic protein-4 (BMP-4) in the development of Barrett’s oesophagus

Investigator: Nick Clemons

Funding: Victorian Cancer Agency Early Career Seed grant, $50k, 1 year 2010

Investigators: Nick Clemons, Christina Fennell (RA)

Sonic Hedgehog signalling in Barrett’s Oesophagus

Investigators: Wayne Phillips, Nick Clemons, D. Neil Watkins (Monash)

Funding: NHMRC Project grant 2010-12 (various sub-projects still ongoing)

Team: Nick Clemons, Christina Fennell (also involves collaboration with David Wang, Dallas, TX – A/Prof in Rhonda Souza’s lab)

Using familial genetics to identify genes involved in the biology of Barrett’s oesophagus

Investigators: Wayne Phillips, Nick Clemons, Cuong Duong, Allison Trainer (PeterMac FCC)

Funding: CCNSW Innovator Grant 2011, $100k, 1 year (Wayne)

Team: Henry To (PROBE-NET funded PhD, currently writing up)

Role of protease-activated receptors in Barrett’s oesophagus and oesophageal adenocarcinoma

Investigators: Wayne Phillips, Nick Clemons

Funding: Unfunded

Team: Shze-Yung Koh (PhD Student currently writing up – Melbourne Research Scholarship-International)

Establishing the role of the stroma to identify putative therapeutic targets and biomarkers in Barrett’s carcinogenesis

Investigators: Nick Clemons, Wayne Phillips, Tim Underwood (Southampton, UK)

Funding: Unfunded (NHMRC Project grant application under review)

Team: Nick Clemons, Christina Fennell (RA)

Characterising a novel patient derived tumour xenograft model for oesophageal adenocarcinoma

Investigators: Nick Clemons, Wayne Phillips, Cuong Duong

Funding: Unfunded (seeking funding from PeterMac Foundation)

Team: Nick Clemons, Christina Fennell (RA), Matt Read (PhD student-surgical trainee), David Liu (PhD student – surgical trainee)

Using a patient derived tumour xenograft model to test molecular targeted therapies in oesophageal adenocarcinoma

Investigators: Nick Clemons, Wayne Phillips, Andrew Barbour, Carleen Cullinane (PeterMac), Cuong Duong

Funding: Unfunded (NHMRC Project grant application in)

Team: Nick Clemons, David Liu (PhD), Christina Fennell (RA)

Tumour initiating cells (cancer stem cells) in oesophageal adenocarcinoma

Investigators: Wayne Philips, Nick Clemons

Funding: Unfunded

Students: Matt Read (PhD)

Investigating the role of PI3K signalling in oesophageal cancer

Investigators: Wayne Phillips, Nick Clemons

Funding: Unfunded

Team: Kristyn Connelly (Masters student)